VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of divalent metal ions--stimulants of uterine contractile activity--on the Mg2+, ATP-dependent transport of Ca2+ in the myometrial sarcolemma fraction

   
Kosterin S.A., Kurskiĭ M.D., Bratkova N.F.
PubMed Id: 3159152
Year: 1985  Volume: 31  Issue: 2  Pages: 97-101
Mn2+, Co2+, Zn2+ and Cu2+ were shown to inhibit the Mg2+-ATP-dependent accumulation of 45Ca2+ in the fraction of cytoplasmic membranes. Mechanism of inhibitory effect of the Me2+ is considered. It is assumed that the cations, exhibiting higher affinity to ATP as compared with Mg2+, contributed to dissociation of the actual substrate of the enzymatic reaction Mg2+-ATP as well as to formation of the chelate complexes of the Me2+-ATP type; these complexes participated in the transport of Ca2+ less effectively as compared with the true substrate Mg2+-ATP. Among the essential factors responsible for an increase in the contractile activity of uterus in response to divalent ions of metals, accumulated into cells, elevation of Ca2+ concentration appears to occur in myocytes due to inhibition of the Mg2+-ATP-dependent output of Ca2+ from myoplasm into interstitial space.
Download PDF:  
Citation:

Kosterin, S. A., Kurskiĭ, M. D., Bratkova, N. F. (1985). Effect of divalent metal ions--stimulants of uterine contractile activity--on the Mg2+, ATP-dependent transport of Ca2+ in the myometrial sarcolemma fraction. Voprosy Meditsinskoi Khimii, 31(2), 97-101.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►