VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol on calcium homeostasis in rats treated with hydrocortisone

   
Karatabanova N.A., Sokolova S.V., Bogoslovskiĭ N.A., Spirichev V.B.
PubMed Id: 3875180
Year: 1985  Volume: 31  Issue: 3  Pages: 112-116
Physiological dose of 1,25(OH)2D3 (0.03 microgram) normalized the phosphorus-calcium metabolism and improved the state of bone tissue in rats treated with hydrocortisone. An increased dose of 1,25(OH)2D3 (0.15 microgram) caused hyperphosphatemia and augmented osteoporotic alterations in the hydrocortisone-treated animals. 24,25(OH)2D3 at a dose of 0.3 mg did not exhibit any positive effect on phosphorus-calcium metabolism and on the state of bone tissue in rats with exogenous hypercorticoidism. At the same time, high doses of 24,25(OH)2D3 increased distinctly the bone tissue density as well as the content of calcium and phosphorus. The most favourable state of the calcium homeostasis and of bone tissue in exogenous hypercorticoidism was observed after simultaneous administration of 1,25(OH)2D3 and 24,25(OH)2D3. These data suggest that a set functionally active metabolites of vitamin D3 should be used in cases of long-term treatment with glucocorticoids.
Download PDF:  
Citation:

Karatabanova, N. A., Sokolova, S. V., Bogoslovskiĭ, N. A., Spirichev, V. B. (1985). Effect of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol on calcium homeostasis in rats treated with hydrocortisone. Voprosy Meditsinskoi Khimii, 31(3), 112-116.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►