VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Prevention of impairment of myocardium metabolism and function in immobilization stress using previous adaptation to short stress exposures

   
Meerson F.Z., Dolgikh V.T., Smolentseva V.N., Batrachenko E.R.
PubMed Id: 4040677
Year: 1985  Volume: 31  Issue: 3  Pages: 41-45
A long-term immobilization stress was shown to cause a distinct enzymemia in rats. Simultaneously, activation of lipid peroxidation and a decrease in glycogen content were observed in myocardium; a distinctly increased penetration of aspartate transferase, lactate- and malate dehydrogenases and RNAase into coronary circulation was found in isolated heart of the animals. These impairments of metabolism were accompanied by a depression of the heart contractile function. The impairments in metabolism and in heart functions might be prevented by preadaptation of the animals to multiple short-term immobilization effects, which did not cause any impairments per se.
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Meerson F.Z., Dolgikh V.T., Smolentseva V.N., Batrachenko E.R. (1985) Voprosy meditsinskoi khimii, 31(3), 41-45.
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