Analysis of the data obtained in experimental (971 animals) and clinical (250 patients) studies with various immobilized proteinases and their inhibitors showed that this approach to enzymotherapy is a perspective one. Immobilized enzymes and inhibitors exceeded distinctly the native preparations in therapeutic efficiency and were devoid of their disadvantages (low stability and autolysis of proteinases, inactivation by inhibitors, occurring in blood and tissues, rapid elimination of the inhibitors from the organism). Wide use of immobilized enzymes and inhibitors in medical practice offered new possibilities in surgery, shortened distinctly the duration of patients treatment and enabled to decrease the doses of drugs and consumption of dressing materials.
Gostishchev V.K. и др., Experimental and clinical use of various forms of immobilized proteinases and their inhibitors //Voprosy meditsinskoi khimii.- 1985. -Т.31. -№ 4. С. 21-24.
Gostishchev V.K. и др., "Experimental and clinical use of various forms of immobilized proteinases and their inhibitors." Voprosy meditsinskoi khimii 31.4 (1985): 21-24.
Gostishchev V.K., Tolstykh P.I., Vasil'kova Z.F., Vlasov L.G., Virnik A.D. (1985). Experimental and clinical use of various forms of immobilized proteinases and their inhibitors. Voprosy meditsinskoi khimii, 31(4), 21-24.