VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Biospecific sorbent for removal of proteinases from biological fluids

   
Valueva T.A., Maklakova I.A., Valuev L.I., Mosolov V.V., Platé N.A.
PubMed Id: 4049784
Year: 1985  Volume: 31  Issue: 4  Pages: 34-39
Sorbents for removal of proteases from biological fluids were synthesized via immobilization of a specific protease inhibitor-ovomucoid from whites of duck eggs--in the bulk of polymeric hydrogel. The sorbents were shown to exhibit high capacity and selectivity in the removal of proteases from the model protein-containing solutions, blood plasma and blood. The sorbents did not affect the blood cells as well as the blood-clotting system. The sorbents were demonstrated to be effective in the removal of proteases from canine blood in acute pancreatitis.
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Valueva T.A., Maklakova I.A., Valuev L.I., Mosolov V.V., Platé N.A. (1985) Voprosy meditsinskoi khimii, 31(4), 34-39.
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