VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Mechanism of enzymatic imprinting induced in rats by an early postnatal administration of galactose

   
Salganik R.I., Solov'eva N.A., Knorre V.L., Tomsons V.P., Iurkina E.A.
PubMed Id: 4049789
Year: 1985  Volume: 31  Issue: 4  Pages: 65-70
Administration of galactose into young rats within an early postnatal period led to alteration in activity of some enzymes involved in utilization of galactose (galactose-1-phosphaturidyl transferase, galactose-6-phosphate dehydrogenase etc) for a long period of the animals life. This stable alteration in activity of adaptive enzymes was characterized as the enzymatic imprinting. After administration of galactose into neonatal animals synthesis of RNA, matrix activity of chromatin, activities of DNA-dependent RNA polymerase and RNA-dependent DNA polymerase were shown to increase in liver tissue of these animals. These alterations are considered as a possible basis for the stable alterations in the genes expression. The elevated activities of DNA-dependent RNA-polymerase and reverse transcriptase were maintained within a long period of the animals life
Download PDF:  
Citation:

Salganik, R. I., Solov'eva, N. A., Knorre, V. L., Tomsons, V. P., Iurkina, E. A. (1985). Mechanism of enzymatic imprinting induced in rats by an early postnatal administration of galactose. Voprosy Meditsinskoi Khimii, 31(4), 65-70.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►