VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Functional state of the hepatocyte cytoplasmic network in heliotrine injury of the rat liver

   
Khakimov Z.Z.
PubMed Id: 4049792
Year: 1985  Volume: 31  Issue: 4  Pages: 80-82
Effect of an alkaloid heliotrine (25 mg per 100 g of body mass) on the functional state of cytoplasmic net in rat hepatocytes was studied. Distinct prolongation of hexenale sleep, decrease in content of protein, cytochromes P-450 and b5 as well as inhibition of oxidative degradation of amidopyrine and aniline in liver microsomal fraction were found. The data obtained suggest that a decrease in the rate of xenobiotics biotransformation in hepatocytes is one of the factors responsible for intoxication of a body and for impairment in pharmacodynamics of the drugs metabolized in liver tissue under conditions of acute toxic hepatites.
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Reference:

Khakimov Z.Z. (1985) Voprosy meditsinskoi khimii, 31(4), 80-82.
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