Effect of the plasma lipoprotein spectrum on the cholesterol level in erythrocyte membranes

Torkhovskaia T.I., Khalilov E.M., Fortinskaia E.S., Kliuchnikova Z.I., Ryzhkova L.K.
PubMed Id: 4049793
Year: 1985  Volume: 31  Issue: 4  Pages: 83-87
Correlation between main patterns of the lipoprotein spectrum in blood plasma and the molar ratio cholesterol/phospholipids (Ch/Pl) in erythrocyte membranes was studied in 256 patients. Distribution of Ch/Pl values was shifted to the right side in the plot for erythrocytes of patients with ischemic disease as compared with healthy persons. The values of the Ch/Pl ratio were increased in hypercholesterolemia. There was no statistically distinct correlation between the Ch/Pl ratio and content of cholesterol and triglycerides in blood plasma as well as with concentration of cholesterol in high density lipoproteins (HDL). At the same time, the ratio Ch/Pl of erythrocytes correlated positively with the index of lipoprotein atherogeneity (kath, total Ch-ChHDL/ChHDL) within the values up to 8.0. Within the higher values the correlation disappeared (a plateau was noted on a plot describing this dependence); no distinct correlation was described in all the groups studied. The data obtained suggest that correlation between the rates of cholesterol introduced and removed from the membranes by means of individual classes of lipoproteins is very important for maintenance of the cholesterol content in erythrocyte membrane. Under conditions of high kath values the discorrelation may indicate the saturation of the erythrocyte membranes with cholesterol and a decrease in the rate of its removal by means of HDL.
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Torkhovskaia T.I., Khalilov E.M., Fortinskaia E.S., Kliuchnikova Z.I., Ryzhkova L.K. (1985) Voprosy meditsinskoi khimii, 31(4), 83-87.
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