VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Changes in the permeability of the blood-brain barrier to oxythiamine

   
Ostrovsky Yu.M., Zimatkina T.I., Oparin D.A.
PubMed Id: 4090356
Year: 1985  Volume: 31  Issue: 5  Pages: 119-121
Activity of transketolase was distinctly inhibited in mice brain after simultaneous administration of hydroxythiamine and 3,3-dimethyl-l-phenyl-l-phthalyl acetic acid. The rate of the enzyme inhibition correlated with an increase of the acid concentration in the mixture studied. The data obtained suggest that permeability of blood-brain barrier for hydroxythiamine was altered in simultaneous administration of the vitamin with some biologically active preparations.
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Ostrovsky Yu.M., Zimatkina T.I., Oparin D.A. (1985) Voprosy meditsinskoi khimii, 31(5), 119-121.
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