VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A

   
Pravdina N.F., Veselovskaia T.V., Smirnov V.D., Galegov G.A.
PubMed Id: 4090358
Year: 1985  Volume: 31  Issue: 5  Pages: 123-125
Deoxyadenylylguanosine (dAdG, 0.2-0.4 mM), affecting the RNA polymerase activity, caused inhibition of transcription of the influenza A virus in presence of precursor AdG by 50-60% and a 80-85% inhibition in absence of the precursor. The inhibitor exhibited its effect independently on the time of addition into an incubation mixture. Addition of 0.5 mM inhibitor into a cultural medium inhibited reproduction of the influenza A virus in a culture of chicken embryonal fibroblasts.
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Pravdina, N. F., Veselovskaia, T. V., Smirnov, V. D., Galegov, G. A. (1985). Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A. Voprosy Meditsinskoi Khimii, 31(5), 123-125.
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