VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Neurogenic dystrophy of the rat kidney and interaction of aldosterone with cytoplasmic and nuclear receptors of kidney tubules

   
Azhipa Ya.I., Akimov I.A., Rodionov A.A.
PubMed Id: 2935998
Year: 1985  Volume: 31  Issue: 5  Pages: 71-75
Dystrophy of rat kidney caused by denervation did not affect the binding of 3H-aldosterone with specific receptors of cytoplasm and nuclei in the small tubular cells. But under conditions of reflectory dystrophy the rates of 3H-aldosterone binding with cytoplasm receptors as well as the hormone transmission from cytoplasmic to nuclear receptors were decreased. The impairments observed in molecular mechanisms of the aldosterone consumption in kidney tubular cells may be responsible for alterations in the tissue sensitivity to the hormone, which was expressed primarily as deterioration of the Na+ reabsorption in the neurodystrophic injury.
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Azhipa, Ya. I., Akimov, I. A., Rodionov, A. A. (1985). Neurogenic dystrophy of the rat kidney and interaction of aldosterone with cytoplasmic and nuclear receptors of kidney tubules. Voprosy Meditsinskoi Khimii, 31(5), 71-75.
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