VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Prostaglandin E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid levels in the blood of immobilized rats: effect of dihydrocucurbitacin D diglucoside

   
Dadaian M.A., Panosian A.G., Karagezian K.G., Gevorkian G.A.
PubMed Id: 3867195
Year: 1985  Volume: 31  Issue: 6  Pages: 98-100
Content of prostaglandin E2 was decreased more than 6-fold in blood plasma of immobilized rats; on the other hand, concentration of 5-hydroxytetraenoic acid was increased more than 3-fold. No distinct alterations were noted in the prostaglandin F2 alpha content. Intraperitoneal preadministration of 0.1 mg/kg of 2 beta, 25-di (beta-D-glucopyranosyl)-16 alpha; 20-dihydroxy-3, 11, 22-trioxo-cucurbit-5-en into the animals, which as far as is known to augment the working capacity of mice, prevented the stress-induced alterations in the eicosanoid contents in blood plasma.
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Dadaian, M. A., Panosian, A. G., Karagezian, K. G., Gevorkian, G. A. (1985). Prostaglandin E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid levels in the blood of immobilized rats: effect of dihydrocucurbitacin D diglucoside. Voprosy Meditsinskoi Khimii, 31(6), 98-100.
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