VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Guanylate cyclase activity of the rabbit myocardium in normal conditions and in allergic states

   
Miroshnichenko V.P., Kriukova G.V., Zubovskaia A.M., Sharlova I.L.
PubMed Id: 2871665
Year: 1986  Volume: 32  Issue: 2  Pages: 109-114
Activity of guanylate cyclase, regulation of the enzyme by means of hormones and other biologically active substances as well as level of cGMP were studied in rabbit myocardium of control animals and in animals with allergic impairment of the tissue. The enzyme was shown to exhibit no sensitivity to acetylcholine and histamine, which appears to occur as a result of the hormone-unspecific desensitization of the corresponding receptors in allergic impairment. Decreased basal activity of guanylate cyclase was accompanied by an increase in content of cGMP in myocardial tissue. This phenomenon was apparently also due to a decrease in phosphodiesterase activity, which is observed under the conditions of this pathology. At the same time, the decrease in the basal activity of guanylate cyclase was caused by impairment in active restoration of the enzyme in the allergic tissue. A decrease in the enzyme activation by means of azide and nitroprusside appears to be due to loss of hem, prosthetic group of the cyclase. Physiological functions of guanylate cyclase are discussed.
Download PDF:  
Citation:

Miroshnichenko, V. P., Kriukova, G. V., Zubovskaia, A. M., Sharlova, I. L. (1986). Guanylate cyclase activity of the rabbit myocardium in normal conditions and in allergic states. Voprosy Meditsinskoi Khimii, 32(2), 109-114.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►