VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of alphalphalpha-tocopherol on glutamic acid metabolism and nicotinamide coenzyme levels in hepatocytes

   
Iakhnina D.N., Agabekova I.I.
PubMed Id: 2873684
Year: 1986  Volume: 32  Issue: 3  Pages: 48-51
Activity of enzymes participating in metabolism of glutamate and content of nicotinamide nucleotides was studied in rat liver tissue within 24 hrs after intramuscular administration of alpha-tocopheryl acetate at doses of 30 mg and 300 mg per kg of body mass. Excess of the vitamin was responsible for a decrease in the ratio NAD+/NADH in cytosol, for stimulation of glutamate dehydrogenase reaction, for a decrease of aspartate aminotransferase activity in mitochondria and of alanine aminotransferase activity in cytosol as well as for an increase of NADPH content.
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Iakhnina, D. N., Agabekova, I. I. (1986). Effect of alphalphalpha-tocopherol on glutamic acid metabolism and nicotinamide coenzyme levels in hepatocytes. Voprosy Meditsinskoi Khimii, 32(3), 48-51.
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