VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339

   
Dushkin M.I., Dolgov A.V.
PubMed Id: 3727478
Year: 1986  Volume: 32  Issue: 3  Pages: 98-101
Injection of Triton WR 1339 into Wistar rats caused a marked increase in contents of free and ester-bound cholesterol, triglycerides, phospholipids and free fatty acids in tissues and a decrease in the activity of lecithin: cholesterol acyltransferase in blood. An increase in concentration of cholesterol esters in tissues was due to a decrease in activity of lysosomal cholesteryl esterase in vivo and in vitro and to an increase in non-sedimentable activities of acid phosphatase, beta-galactosidase and cholesteryl esterase. The decrease in proteolytic degradation of cholesterol esters was accompanied by an increase in the activity of tissue cytoplasmic cholesteryl esterase and by a decrease in activity of acyl-CoA: cholesterol O-acyltransferase in liver tissue.
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Dushkin, M. I., Dolgov, A. V. (1986). Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339. Voprosy Meditsinskoi Khimii, 32(3), 98-101.
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