VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Absorption of iodinated plasma lipoproteins by subpopulations of hepatocytes and sinusoid cells of the rat liver

   
Panin L.E., Usynin I.F., Poliakov L.M.
PubMed Id: 3765488
Year: 1986  Volume: 32  Issue: 4  Pages: 106-110
Individual hepatocytes and sinusoid cells were isolated from rat liver tissue within various periods after intravenous administration of 125I-lipoproteins of very low (VLDL), low (LDL) and high density (HDL). Estimation of the radioactivity per 1 mg of the cell protein showed that within 30 min absorption of VLDL was 6-fold, LDL--4-fold and HDL--14-fold as high as compared with hepatocytes. Within the first 30 min sinusoid cells accumulated 54% of 125I-HDL, while hepatocytes contained 46% of the labelled lipoprotein, absorbed in liver tissue. On the other hand, within 6 hrs and 12 hrs hepatocytes contained 80-88% and sinusoid cells--17-20% of the label. After fractionation of hepatocytes in Ficoll density gradient all the populations of hepatocytes were shown to absorb effectively VLDL fraction, while HDL and LDL were accumulated in 'heavy' (centrolobular) hepatocytes. Penetration of the lipoproteins in hepatocytes appears to be carried out by means of intracellular transport from sinusoid cells.
Download PDF:  
Citation:

Panin, L. E., Usynin, I. F., Poliakov, L. M. (1986). Absorption of iodinated plasma lipoproteins by subpopulations of hepatocytes and sinusoid cells of the rat liver. Voprosy Meditsinskoi Khimii, 32(4), 106-110.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►