VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes

   
Sushko L.I., Sheĭbak V.M., Abakumov G.Z., Moĭseenok A.K.
PubMed Id: 3765494
Year: 1986  Volume: 32  Issue: 4  Pages: 20-24
After subcutaneous administration into male rats of 4-phosphopantothenic acid and pantethine during 10 days at a dose equivalent to 30 mg/kg of calcium pantothenate total content of CoA was increased in liver tissue. Both these preparations activated the liver endoplasmic reticulum monooxygenase system mainly at the step of substrate hydroxylation. The phenomenon observed appears to occur due to activation of cytochrome P-450 biosynthesis and/or to alterations in phospholipid composition of microsomal membranes.
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Sushko, L. I., Sheĭbak, V. M., Abakumov, G. Z., Moĭseenok, A. K. (1986). Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes. Voprosy Meditsinskoi Khimii, 32(4), 20-24.
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