VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Changes in the kinetic characteristics of reactions catalyzed by erythrocyte delta-aminolevulinate dehydratase in experimental lead poisoning in rats

   
Okunev I.A., Semenova L.S., Arkhipova O.G., Kagan Z.S.
PubMed Id: 3765504
Year: 1986  Volume: 32  Issue: 4  Pages: 94-97
An increase in values of both kinetic parameters (Km and Vmax) of the delta-aminolevulinate dehydratase reaction was observed in blood of rats poisoned with lead. The Km value of the reaction was increased, while Vmax--decreased, after addition of Pb2+ into rat blood in vitro. The results obtained as well as the data published in literature suggest that a compensatory mechanism appears to function in vivo, where a substrate, delta-aminolevulenic acid, plays a triggering role.
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Okunev, I. A., Semenova, L. S., Arkhipova, O. G., Kagan, Z. S. (1986). Changes in the kinetic characteristics of reactions catalyzed by erythrocyte delta-aminolevulinate dehydratase in experimental lead poisoning in rats. Voprosy Meditsinskoi Khimii, 32(4), 94-97.
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