VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Diagnostic value of determining neutral alpha-glucosidase and N-acetyl-beta-D-hexosaminidase activity in the urine in kidney pathology

   
Lukomskaia I.S., Lavrenova T.P., Tomilina N.A., Zubkin M.L., Fedorova N.D.
PubMed Id: 2946105
Year: 1986  Volume: 32  Issue: 5  Pages: 112-119
As shown in studies of 123 patients with various nephropathies, activities of alpha-glucosidase and N-acetyl-beta-D-hexosaminidase in urine of the patients correlated with severity and stages of these diseases; at the same time, simultaneous estimation of both enzymatic activities in urine was shown to be more informative in diagnostic of kidney impairments. Low values of correlation coefficient (r = 0.35 +/- 0.09) between daily excretion of protein and the activity of neutral alpha-glucosidase in urine showed that the enzyme activity did not depend on proteinuria and was independent test for kidney impairment. Estimation of alpha-glucosidase activity could be used for control of the therapy; the enzymatic activity in urine correlated distinctly with the clinico-laboratory patterns of the patients studied.
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Lukomskaia, I. S., Lavrenova, T. P., Tomilina, N. A., Zubkin, M. L., Fedorova, N. D. (1986). Diagnostic value of determining neutral alpha-glucosidase and N-acetyl-beta-D-hexosaminidase activity in the urine in kidney pathology. Voprosy Meditsinskoi Khimii, 32(5), 112-119.
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