VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Incorporation and release of cholesterol from plasma membranes of hepatocytes and Zajdela hepatoma cells

   
Ivanova L.I., Khalilov E.M., Gorbatenkova E.A., Archakov A.I., Lopukhin I.M.
PubMed Id: 3022483
Year: 1986  Volume: 32  Issue: 5  Pages: 62-67
Molar ratio of cholesterol/phospholipids was decreased in Zajdela hepatoma cell membranes as compared with rat normal hepatocytes. Microviscosity of lipid bilayer was increased in membranes of normal and malignant cells, while the activity of Na+, K+-ATPase and 5'-nucleotidase was decreased during introduction of cholesterol into the cell membranes. As compared with control groups the duration of life was increased in the group of animals implanted with Zajdela hepatoma cells modified by cholesterol. The data obtained suggest that an increase in microviscosity of membranes in tumoral cells, enriched with cholesterol, might inhibit their mitotic divisions.
Download PDF:  
Citation:

Ivanova, L. I., Khalilov, E. M., Gorbatenkova, E. A., Archakov, A. I., Lopukhin, I. M. (1986). Incorporation and release of cholesterol from plasma membranes of hepatocytes and Zajdela hepatoma cells. Voprosy Meditsinskoi Khimii, 32(5), 62-67.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►