VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Stimulation of mitochondrial oxidative enzymes in acute cooling and its catecholamine mechanisms

   
Kulinskiĭ V.I., Medvedev A.I., Kuntsevich A.K.
PubMed Id: 3022485
Year: 1986  Volume: 32  Issue: 5  Pages: 84-88
Acute cooling of rats led to stimulation of NAD+-dependent isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and NAD(P)+-transhydrogenase (TH) but did not affect the NADP+-ICDH activity in liver, heart and skeletal muscle mitochondria. After pretreatment of the animals with propranolol the stimulating effect was decreased, thus suggesting that endogenous catecholamines and beta-adrenoreceptors are of importance in activation of NAD+-ICDH, SDH and TH. The effects of cooling, noradrenaline and cAMP did not summarize. Role of catecholamines in stimulation of mitochondrial oxidative enzymes under conditions of cooling is discussed.
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Kulinskiĭ, V. I., Medvedev, A. I., Kuntsevich, A. K. (1986). Stimulation of mitochondrial oxidative enzymes in acute cooling and its catecholamine mechanisms. Voprosy Meditsinskoi Khimii, 32(5), 84-88.
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