VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Fibronectin fragmentation unmasks the activity stimulating DNA and RNA biosynthesis in granulation tissue cells in vitro

   
Zlatopol'skii A.D., Zaidenberg M.A., Berman A.E., Mazurov V.I., Karelin A.A.
PubMed Id: 2437701
Year: 1987  Volume: 33  Issue: 1  Pages: 116-118
Human blood plasma fibronectin decreased slightly the incorporation of precursors into nucleic acids of granulation tissue culture cells. A slight fragmentation of fibronectin, where the fragments with 180-200 kD molecular mass were developed, led to occurrence of the activity 2-fold stimulating the DNA synthesis. After more effective proteolysis using plasmin and trypsin the stimulating effect of fibronectin fragments on synthesis of nucleic acids maintained and constituted 165 +/- 12% and 127 +/- 7% for DNA and RNA, respectively.
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Zlatopol'skii, A. D., Zaidenberg, M. A., Berman, A. E., Mazurov, V. I., Karelin, A. A. (1987). Fibronectin fragmentation unmasks the activity stimulating DNA and RNA biosynthesis in granulation tissue cells in vitro. Voprosy Meditsinskoi Khimii, 33(1), 116-118.
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