VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Radioimmunological assay of plasma levels of alpha-gamma-endorphins in healthy donors and patients with endogenous depression

   
Dmitriev A.D., Tennov A.V., Tsutsul'kovskaia M.Ia., Beliaev B.S., Kizim E.A.
PubMed Id: 2437703
Year: 1987  Volume: 33  Issue: 1  Pages: 88-91
Radioimmunological procedure enabled to estimate alpha- and gamma-endorphins in human blood plasma without pre-extraction. Basal level of these neuropeptides in peripheric blood plasma of 18 healthy donors constituted: C alpha = 392 +/- 244 pg/ml and C gamma = 20.6 +/- 9.1 pg/ml. Content of these endorphins in blood plasma did not depend on age and sex. Concentration of alpha- and gamma-endorphins were shown to correlate in peripheric blood (r = 0.88); this suggests the overall mechanisms for regulation of their synthesis, secretion and degradation. At the same time, distinct differences in concentrations of alpha- and gamma-endorphins in blood plasma were not found in groups of healthy donors and of patients with endogenous psychoses and pronounced depressive symptoms.
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Dmitriev, A. D., Tennov, A. V., Tsutsul'kovskaia, M. Ia., Beliaev, B. S., Kizim, E. A. (1987). Radioimmunological assay of plasma levels of alpha-gamma-endorphins in healthy donors and patients with endogenous depression. Voprosy Meditsinskoi Khimii, 33(1), 88-91.
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