VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of acrylates on the level and isozyme composition of cytochrome P-450 in rat liver microsomes

   
Kotlovskiĭ I.V., Gutkina N.I., Guliaeva L.M., Dovgiĭ A.I., Andrianov N.V.
PubMed Id: 3577066
Year: 1987  Volume: 33  Issue: 1  Pages: 96-100
Content of cytochrome P-450 was decreased in rat liver microsomes, pretreated with phenobarbital, after incubation with acrylamide, methyl methacrylate and butyl methacrylate in presence of NADPH in vitro. The phenomenon was not observed in the analogous experiments but carried out without NADPH, thus suggesting the microsomal metabolism of the acrylates. At the same time, after intraperitoneal administration of acrylamide 0.4 mmole/kg, methyl methacrylate 6.0 mmole/kg and butyl methacrylate 9.0 mmole/kg within 3 days into intact and protected with phenobarbital rats alterations in total content of cytochrome P-450 were not observed. All the acrylates studied exhibited the slight inducing effect on cytochrome P-450b but did not affect the cytochrome P-450c. Methyl- and butyl methacrylates decreased distinctly the content of cytochrome P-450 isoenzyme with molecular mass of 48,000 daltons.
Download PDF:  
Citation:

Kotlovskiĭ, I. V., Gutkina, N. I., Guliaeva, L. M., Dovgiĭ, A. I., Andrianov, N. V. (1987). Effect of acrylates on the level and isozyme composition of cytochrome P-450 in rat liver microsomes. Voprosy Meditsinskoi Khimii, 33(1), 96-100.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►