VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Biologically active metabolites of membrane glycerophospholipids in normal conditions and in pathologic states

   
Vel'tishchev Iu.E., Iur'eva E.A., Vozdvizhenskaia E.S.
PubMed Id: 3300020
Year: 1987  Volume: 33  Issue: 2  Pages: 2-9
The data on biological role of numerous phospholipid metabolites, main part of which is localized in cell membranes, are reviewed. Many of these metabolites are related to slowly reacting substances of anaphylaxis and participate in allergic and inflammatory reactions. Conditions of biosynthesis of phospholipid active metabolites are characterized in the reactions of lipid peroxidation, N-acetylation, formation of Shiff bases, enaminales via transacetylation, by the action of phospholipases, lipooxygenase, cyclooxygenase, by formation of plasmalogens, phosphomonolipids, phospholipid diols. Role of individual phospholipid metabolites in normal and pathological states is discussed.
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Vel'tishchev, Iu. E., Iur'eva, E. A., Vozdvizhenskaia, E. S. (1987). Biologically active metabolites of membrane glycerophospholipids in normal conditions and in pathologic states. Voprosy Meditsinskoi Khimii, 33(2), 2-9.
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