VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Formation of streptokinase-heparin complexes and their properties

   
Nikandrov V.N., Votiakov V.I., Naumovich S.A., Vorob'eva G.V., Tsymanovich S.G.
PubMed Id: 3604141
Year: 1987  Volume: 33  Issue: 2  Pages: 54-58
Streptokinase and heparin developed complex at the ratio 3.2:1, w/w, respectively, and neutral values of pH, which was registered by means of thin-layer chromatography and differential UV-spectroscopy. IR-, differential UV- and CD-spectroscopic methods showed that secondary and tertiary structures of streptokinase were altered in the complex. Streptokinase containing in the complex exhibited the higher thermostability at 50 degrees as compared with native protein. After intravenous administration of the complex into rabbits more distinct alterations were observed in thrombin time, blood clot lysis and in blood plasma fibrinolytic activity as compared with native streptokinase effect.
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Nikandrov, V. N., Votiakov, V. I., Naumovich, S. A., Vorob'eva, G. V., Tsymanovich, S. G. (1987). Formation of streptokinase-heparin complexes and their properties. Voprosy Meditsinskoi Khimii, 33(2), 54-58.
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