VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Changes in the fatty acid composition of erythrocyte and platelet membranes after diet therapy in patients with hyperlipoproteinemia type II

   
Korf I.I., Meshcheriakova V.A., Samsonov M.A., Chepurnenko N.V., Koshechkin V.A.
PubMed Id: 3630021
Year: 1987  Volume: 33  Issue: 3  Pages: 73-77
Fatty acid spectrum of blood plasma, erythrocyte, and thrombocyte membranes as well as its alterations after diet therapy, containing polyunsaturated/saturated fatty acids at the ratio of I and less than 350 mg of cholesterol per a day, was studied in patients with hereditary hypercholesterolemia using gas chromatography. Content of linoleic acid was increased and that of oleic and arachidonic acids--decreased in lipids of the patients blood plasma as compared with healthy persons; an increase of linoleic acid was also detected in thrombocyte lipids. Alterations in fatty acid spectrum of erythrocyte membranes were less pronounced. After the course of diet therapy within I month a further increase in content of linoleic acid was observed in blood plasma. Under these conditions efficiency of essential fatty acids incorporation into lipid structures of thrombocyte membranes was higher and of erythrocytes--lower in the patients as compared with healthy persons. Possible alimentary correction of fatty acid spectrum in blood lipids is discussed.
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Korf, I. I., Meshcheriakova, V. A., Samsonov, M. A., Chepurnenko, N. V., Koshechkin, V. A. (1987). Changes in the fatty acid composition of erythrocyte and platelet membranes after diet therapy in patients with hyperlipoproteinemia type II. Voprosy Meditsinskoi Khimii, 33(3), 73-77.
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