VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Mechanism of activation of the kallikrein-kinin system in human plasma in stomach and duodenal ulcer

   
Dotsenko V.L., Serova N.B., Logunov A.I., Lebkova N.P., Iarovaia G.A.
PubMed Id: 3660730
Year: 1987  Volume: 33  Issue: 4  Pages: 104-109
Activity of kallikrein and content of prekallikrein were studied in blood serum of patients with gastroduodenal ulcer accompanied (or not accompanied) by hemorrhage. The rate of the kallikrein-kinin system activation was higher under conditions of the disease complicated by hemorrhage. Extracts of bioptic samples obtained from ulcerous zones as well as the extracts of leukocytes were shown to activate prekallikrein and Hageman factor in human blood plasma. At the same time, the activating effect of these extracts was distinctly lowered in the ulcer accompanied by hemorrhage. The phenomenon observed might occur due to high intensity of polymorphonuclear leukocytes degranulation during hemorrhage in the ulcer area.
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Dotsenko V.L., Serova N.B., Logunov A.I., Lebkova N.P., Iarovaia G.A. (1987) Voprosy meditsinskoi khimii, 33(4), 104-109.
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