VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The role of cell membrane damage in the development of hormone-resistant kidney diseases in children

   
Krylov V.I., Petrushina A.D., Moreva G.V., Grannik G.K., Durygin A.N., Zhuravleva T.D., Portnyagina G.V.
PubMed Id: 3660735
Year: 1987  Volume: 33  Issue: 4  Pages: 22-24
Distinct increase in content of lysophosphatidyl choline, dehydrocholesterol, decrease in concentration of phosphatidyl ethanolamine simultaneously with high level of diene conjugates and Schiff bases were found in children with hormone-resistant form of nephrotic glomerulonephritis as compared with children suffering from a hormone-dependent form of the disease. Peroxidation of membrane lipids appears to cause a destabilization of cell membranes, which is responsible for development of hormone-resistance.
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Krylov, V. I., Petrushina, A. D., Moreva, G. V., Grannik, G. K., Durygin, A. N., Zhuravleva, T. D., Portnyagina, G. V. (1987). The role of cell membrane damage in the development of hormone-resistant kidney diseases in children. Voprosy Meditsinskoi Khimii, 33(4), 22-24.
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