VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of lysosomal hydrolases in the rat liver, spleen and thymus during antigenic stimulation and vitamin A administration

   
Vasil'ev A.V., Konovalova L.S., Pletsityi K.D., Ponomareva L.G., Tutel'ian V.A.
PubMed Id: 3686899
Year: 1987  Volume: 33  Issue: 5  Pages: 81-83
Total activity of cathepsins A, B, C, D as well as of arylsulfatases A and B were studied in liver, spleen, thymus tissues of rats after peroral administration of vitamin A at a daily dose of 30,000 IU within 3 days and the following immunization with sheep erythrocytes. Under conditions of immunization with T-dependent antigen the immunostimulating effect of vitamin A was accompanied by the distinct activation of lysosomal proteinases in liver and spleen tissues but did not affect the functional state of thymocyte lysosomal apparatus. The reaction of lysosomal hydrolases observed was considered as one of biochemical steps in development of humoral immunity.
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Vasil'ev, A. V., Konovalova, L. S., Pletsityi, K. D., Ponomareva, L. G., Tutel'ian, V. A. (1987). Activity of lysosomal hydrolases in the rat liver, spleen and thymus during antigenic stimulation and vitamin A administration. Voprosy Meditsinskoi Khimii, 33(5), 81-83.
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