VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats

   
Davletov E.G., Saliakhova R.M., Kamilov F.Kh.
PubMed Id: 3445545
Year: 1987  Volume: 33  Issue: 6  Pages: 51-56
Impairments of protein metabolism, expressed as predominance of catabolism over anabolism and hypoproteinemia, were observed in one month old rats with experimental burns of the IIIA-IIIB degree, when 20-25% of a body surface was impaired. After administration of steroid drugs (retabolyl at a dose of 1 mg/100 g of body mass or oxymetacyl--4-methyl-5-oxyuracil---at a dose of 5 mg/100 g of body mass) content of protein and urea normalized in blood serum, activity of cathepsin D decreased in tissues, the rate of 35S-methionine incorporation into tissue proteins increased. The pyrimidine derivative oxymetacyl exhibited higher effect on protein metabolism in burns of preadolescent rats as compared with retabolyl.
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Davletov, E. G., Saliakhova, R. M., Kamilov, F. Kh. (1987). Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats. Voprosy Meditsinskoi Khimii, 33(6), 51-56.
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