VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of ethanol and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart

   
Antonenkov V.D., Gusev V.A., Krasnova S.N.
PubMed Id: 3445547
Year: 1987  Volume: 33  Issue: 6  Pages: 59-64
Tissue-specific effects of ethanol and aminotriazole were studied in rats. Simultaneous administration of both these drugs caused alcoholic cardiomyopathy in the animals, while liver tissue impairment was not detected. Effect of ethanol and aminotriazole on content of reduced glutathione as well as on activity of catalase, superoxide dismutase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase, the enzymes participating in the antioxidation system, were also studied in liver and heart tissues. After repeated simultaneous or separate administration of these drugs concentration of glutathione and glutathione-S-transferase activity were elevated in liver tissue. Acute and repeated administration of a notriazole led to inactivation of catalase the same time, superoxide dismutase was inhibited in liver tissue as a result of the drug repeated administration. Activity of glucose phosphate dehydrogenase was increased in liver tissue of control rats, the diet of which contained isocaloric carbohydrates instead of ethanol.
Download PDF:  
Citation:

Antonenkov, V. D., Gusev, V. A., Krasnova, S. N. (1987). Effect of ethanol and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart. Voprosy Meditsinskoi Khimii, 33(6), 59-64.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►