VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Soluble and membrane-bound forms of neutral alpha-glucosidase in human urine in normal conditions and in kidney diseases

   
Ushakova N.A., Lavrenova T.P., Kazlas E.V., Tomilina N.A., Zubkin M.L., Fedorova N.D., Lukomskaya I.S.
PubMed Id: 3285588
Year: 1988  Volume: 34  Issue: 1  Pages: 120-125
Soluble and membrane-bound forms of neutral alpha-glucosidase, which are immunologically similar to the corresponding forms of kidney enzymes, were found in urine of healthy persons and of patients with kidney impairments. Membrane-bound enzyme was only slightly active in urine of healthy persons and constituted 3-10% of total urine activity although the ratio of membrane-bound enzyme was simultaneously elevated under pathological conditions. The increased rate of soluble enzyme secretion was responsible for distinct activation of neutral alpha-glucosidase in urine of the patients with kidney impairments.
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Ushakova, N. A., Lavrenova, T. P., Kazlas, E. V., Tomilina, N. A., Zubkin, M. L., Fedorova, N. D., Lukomskaya, I. S. (1988). Soluble and membrane-bound forms of neutral alpha-glucosidase in human urine in normal conditions and in kidney diseases. Voprosy Meditsinskoi Khimii, 34(1), 120-125.
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