VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine

   
Dolgikh V.T.
PubMed Id: 3130722
Year: 1988  Volume: 34  Issue: 1  Pages: 33-38
Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resuscitation. Severity of postresuscitation period correlated with the level of deteriorations observed in energy metabolism. Preadministration of gamma-aminobutyric acid, ionol and gutimine decreased these impairments as well as the postresuscitation lethality. Considering the final results of resuscitation the efficiency of the drugs studied might be arranged in a following order: gamma-aminobutyric acid, ionol, gutimine.
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Dolgikh, V. T. (1988). Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine. Voprosy meditsinskoi khimii, 34(1), 33-38.
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