VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Pharmacokinetics of dalargin

   
Kalenikova E.I., Dmitrieva O.F., Korobov N.V., Zhukovskiĭ S.V., Tishchenko V.A., Vinogradov V.A.
PubMed Id: 3369130
Year: 1988  Volume: 34  Issue: 1  Pages: 75-83
Pharmacokinetics of a new anti-ulcer drug, synthetic opioid hexapeptide dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg), which is an analogue of Leu-enkephalin, was studied in rats. Distribution and metabolism of 3H-Tyr-dalargin were examined after intravenous administration at a dose of 150 mg/kg. Main Tyr-containing metabolites of dalargin were detected and dynamics of their concentrations was evaluated in blood within 1 hr after administration. Kinetic curve of dalargin was described as three-exponential function.
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Kalenikova, E. I., Dmitrieva, O. F., Korobov, N. V., Zhukovskiĭ, S. V., Tishchenko, V. A., Vinogradov, V. A. (1988). Pharmacokinetics of dalargin. Voprosy Meditsinskoi Khimii, 34(1), 75-83.
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