VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of uterine contraction stimulants on active and passive transport of Ca2+ in the fraction of myometrium sarcolemma

   
Kurskiĭ M.D., Shinlova O.P., Fomin V.P., Kosterin S.A.
PubMed Id: 3400181
Year: 1988  Volume: 34  Issue: 2  Pages: 113-117
Effect of drugs (quinine, sigetine, isoverine and pachycarpine) stimulating uterine contraction on active and passive Ca2+ transport was studied in cow myometrium sarcolemma. Isoverine and pachycarpine at concentrations 10(-6)-10(-2) M did not affect the systems of Ca2+ transport. Quinine at concentrations above 10(-3) M decreased the rate of Mg2+ ATP-dependent accumulation of Ca2+ and stimulated passive elimination of the cation from vesicles due to an increase in unspecific permeability of myometrial sarcolemma. Sigetine (10(-6) = 10(-2) M) did not affect the Ca2+ passive transport but inhibited uncompetitively the Mg2+ ATP-dependent accumulation of Ca2+ in sarcolemmal vesicles. Effect of sigetine as a stimulator of the uterine contractile activity is apparently based on inhibition of the calcium pump in plasmatic membrane of myometrial cells.
Download PDF:
Reference:

Kurskiĭ M.D., Shinlova O.P., Fomin V.P., Kosterin S.A. (1988) Voprosy meditsinskoi khimii, 34(2), 113-117.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
        

© Institute of Biomedical Chemistry, Moscow, Russia