VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of uterine contraction stimulants on active and passive transport of Ca2+ in the fraction of myometrium sarcolemma

   
Kurskiĭ M.D., Shinlova O.P., Fomin V.P., Kosterin S.A.
PubMed Id: 3400181
Year: 1988  Volume: 34  Issue: 2  Pages: 113-117
Effect of drugs (quinine, sigetine, isoverine and pachycarpine) stimulating uterine contraction on active and passive Ca2+ transport was studied in cow myometrium sarcolemma. Isoverine and pachycarpine at concentrations 10(-6)-10(-2) M did not affect the systems of Ca2+ transport. Quinine at concentrations above 10(-3) M decreased the rate of Mg2+ ATP-dependent accumulation of Ca2+ and stimulated passive elimination of the cation from vesicles due to an increase in unspecific permeability of myometrial sarcolemma. Sigetine (10(-6) = 10(-2) M) did not affect the Ca2+ passive transport but inhibited uncompetitively the Mg2+ ATP-dependent accumulation of Ca2+ in sarcolemmal vesicles. Effect of sigetine as a stimulator of the uterine contractile activity is apparently based on inhibition of the calcium pump in plasmatic membrane of myometrial cells.
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Kurskiĭ, M. D., Shinlova, O. P., Fomin, V. P., Kosterin, S. A. (1988). Effect of uterine contraction stimulants on active and passive transport of Ca2+ in the fraction of myometrium sarcolemma. Voprosy Meditsinskoi Khimii, 34(2), 113-117.
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