VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Comparison of ethanol and acetaldehyde interactions with chromatin components of cell nuclei from the rat liver

   
Bozhko G.Kh., Khomenko E.I.
PubMed Id: 3400187
Year: 1988  Volume: 34  Issue: 2  Pages: 19-23
Interaction of ethanol and acetaldehyde with structures of rat liver cells nuclei was studied in vivo and in vitro using labelled compounds. After injection of 14C-ethanol and 14C-acetaldehyde into control and alcohol-consuming animals the radioactivity was found in carioplasm, non-histone proteins and residual DNA-protein complex. Relative value of specific radioactivity of all the chromatin components studied was practically similar after administration of either ethanol or acetaldehyde. The effect of such aldehyde dehydrogenase inhibitor as teturam led to a significant increase of the label incorporation into chromatin proteins. Acetaldehyde was shown to bind intensively with the isolated chromatin matrix. At the same time, radioactivity was not found in chromatin after incubation with labelled ethanol. The data obtained suggest that alterations in structure and functions of genetic cell apparatus under conditions of ethanol intoxication occurred mainly due to the action of acetaldehyde as a result of ethanol reduction.
Download PDF:
Citation:

Bozhko, G. Kh., Khomenko, E. I. (1988). Comparison of ethanol and acetaldehyde interactions with chromatin components of cell nuclei from the rat liver. Voprosy meditsinskoi khimii, 34(2), 19-23.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)