VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Regulation of the activity of the oxoglutarate dehydrogenase complex of animal origin (review)

   
Strumilo S.A.
PubMed Id: 3041670
Year: 1988  Volume: 34  Issue: 2  Pages: 2-7
Recent data on regulation of the multi-enzyme oxoglutarate dehydrogenase complex from pigeon breast muscle, porcine heart, bovine adrenal glands and kidney are reviewed. The most characteristic property of the complex consists in activation of the trigger oxoglutarate dehydrogenase component by and ATP. Action of these agents is more pronounced at low concentrations of 2-oxoglutarate and is directed towards alteration of the substrate half-saturation value SO.5. The adrenal oxoglutarate dehydrogenase complex exhibits positive cooperativity of allosteric ADP-binding sites which improved its sensitivity to variations in the effector concentration. The oxoglutarate dehydrogenase complex appears to be not only an important functional component but also is a regulatory unit of the Krebs cycle.
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Strumilo, S. A. (1988). Regulation of the activity of the oxoglutarate dehydrogenase complex of animal origin (review). Voprosy Meditsinskoi Khimii, 34(2), 2-7.
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