VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

14C-procollagen secretion by human embryonal fibroblasts with diploid and trisomic chromosome complement

   
Freĭdin M.I., Solov'eva N.V., Kukharenko V.I., Del'vig A.A.
PubMed Id: 3400194
Year: 1988  Volume: 34  Issue: 2  Pages: 72-75
Secretion of procollagen was studied in human embryonal fibroblasts with diploid chromosomes as well as in fibroblasts obtained from fetuses after spontaneous abortion from patients with trisomy by chromosome 7. The rate of procollagen secretion was approximately similar in these cells; the protein was shown to accumulate in intracellular matrix of diploid fibroblasts, while it did not occur in the matrix of aneuploid fibroblasts. Content of polymeric tubulin was decreased in fibroblasts with trisomy as compared with diploid cells. Impairment of the intracellular matrix structure in the cells with trisomy appears to be responsible for deterioration of morphogenesis in human chromosome anomalies
Download PDF:  
Citation:

Freĭdin, M. I., Solov'eva, N. V., Kukharenko, V. I., Del'vig, A. A. (1988). 14C-procollagen secretion by human embryonal fibroblasts with diploid and trisomic chromosome complement. Voprosy Meditsinskoi Khimii, 34(2), 72-75.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►