VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency

   
Vasil'ev A.V., Konovalova L.S., Pletsityi K.D., Ponomareva L.G., Tutel'ian V.A.
PubMed Id: 3400200
Year: 1988  Volume: 34  Issue: 2  Pages: 97-99
Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.
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Vasil'ev, A. V., Konovalova, L. S., Pletsityi, K. D., Ponomareva, L. G., Tutel'ian, V. A. (1988). Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency. Voprosy meditsinskoi khimii, 34(2), 97-99.
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