VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Glycosaminoglycans and beta-glucuronidase in peripheral blood cells and biological fluids of patients with rheumatoid arthritis

   
Volkova Z.I., Astakhova T.A., Trofimova T.M., Mul'diiarov P.Ia.
PubMed Id: 3420812
Year: 1988  Volume: 34  Issue: 3  Pages: 53-59
Content of glycosaminoglycans and beta-glucuronidase activity were measured in leukocytes, blood serum and urine of patients with rheumatoid arthritis. Concentration of glycosaminoglycans was increased in blood serum and urine of the patients. The most distinct increase as compared with healthy persons in content of these substances was found in leukocytes of the patients with joint form of rheumatoid arthritis. Activity of beta-glucuronidase was also elevated in cells of peripheral blood, whereas content of protein was decreased in these cells. The enzymatic activity was reduced in the fraction of polymorphonuclear leukocytes of the patients as shown by estimation of the activity per 10(6) cells after fractionation using the Ficoll-verografin procedure. Deficiency of beta-glucuronidase activity in polymorphonuclear leukocytes appears to be among the factors responsible for excess of glycosaminoglycans in blood serum and urine of the patients as well as for chronic inflammation under conditions of rheumatoid arthritis.
Download PDF:  
Citation:

Volkova, Z. I., Astakhova, T. A., Trofimova, T. M., Mul'diiarov, P. Ia. (1988). Glycosaminoglycans and beta-glucuronidase in peripheral blood cells and biological fluids of patients with rheumatoid arthritis. Voprosy Meditsinskoi Khimii, 34(3), 53-59.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►