VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Gamma-aminobutyric acid metabolism in the rat brain after administration of nootropic agents

   
Karaseva T.L., Tsapenko Zh.N., Golovenko N.Ia., Timofeeva S.E., Luk'ianenko N.G.
PubMed Id: 2971290
Year: 1988  Volume: 34  Issue: 3  Pages: 81-84
N,N-bis-pyrrolidonomethyl-diaza - 18-crown-6 and piracetam, which are structural analogues of gamma-aminobutyric acid (GABA) and exhibit nootropic properties, affected the GABA metabolism, the content of total protein, DNA and RNA in rat brain after long-term administration at pharmacologically active doses of 100 mg/kg and 400 mg/kg, respectively. As compared with control values, content of GABA in rat brain was increased by 40% after administration of N,N-bis-pyrrolodonomethyl-diaza-18-crown-6 and by 28%--after treatment with piracetam. At the same time, activity of GABA transaminase was decreased by 49.4% and 39.8%, respectively, while the decarboxylase activity was unaltered.
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Karaseva, T. L., Tsapenko, Zh. N., Golovenko, N. Ia., Timofeeva, S. E., Luk'ianenko, N. G. (1988). Gamma-aminobutyric acid metabolism in the rat brain after administration of nootropic agents. Voprosy Meditsinskoi Khimii, 34(3), 81-84.
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