VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method

   
Gorshkova I.N., Noeva E.A., Polesskiĭ V.A., Perova N.V., Ruuge E.K.
PubMed Id: 2844020
Year: 1988  Volume: 34  Issue: 3  Pages: 85-90
Thermo-induced structural reorganization in human high density lipoproteins subclasses HDL2 and HDL3 have been studied by means of electronic paramagnetic resonance method. A number of spin labels were used: 5- and 16-DOXYL stearates, DOXYL-labelled derivatives of pentadecane, phosphatidyl choline and sphingomyelin. In hypoalphalipoproteinemia one of the thermo-induced transitions in HDL2 (at 23-30 degrees) was not observed. In coronary heart disease the critical temperature for HDL3 was shifted from the physiological values and located at 42-48 degrees. The data obtained are discussed from the point of view of their potential role in atherogenesis.
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Gorshkova, I. N., Noeva, E. A., Polesskiĭ, V. A., Perova, N. V., Ruuge, E. K. (1988). A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method. Voprosy Meditsinskoi Khimii, 34(3), 85-90.
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