VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of vitamin K deficiency in rats on various enzyme systems participating in energy metabolism

   
Kolesova G.M., Sokol'nikov A.A., Kodentsova V.M., Klimova O.A., Sergeev I.N.
PubMed Id: 3195131
Year: 1988  Volume: 34  Issue: 4  Pages: 46-51
In alimentary deficiency of vitamin K in rats, accompanied by an increase in the prothrombin time by 30%, activity of kidney creatine kinase and of blood serum alkaline phosphatase was unaltered, while the activity of alkaline phosphatase in small intestinal mucose was decreased by 20% and that of creatine kinase from skeletal muscles--by 10%. In vitamin K-deprived animals the rate of coupling between respiration and mitochondrial phosphorylation was decreased, which might be due to alteration in the NADH-dehydrogenase complex. Menadion reductase activity and cyanide-resistant respiration of mitochondria were unaltered in presence of menadion. Palmitic acid effectively activated of mitochondrial respiration in vitamin K-deprived animals (contrary to the control rats). This effect appears to occur as a result of structural alterations in mitochondria depending on vitamin K level in the organelles.
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Kolesova, G. M., Sokol'nikov, A. A., Kodentsova, V. M., Klimova, O. A., Sergeev, I. N. (1988). The effect of vitamin K deficiency in rats on various enzyme systems participating in energy metabolism. Voprosy Meditsinskoi Khimii, 34(4), 46-51.
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