Distinct activation of both nonenzymatic and enzymatic forms of lipid peroxidation, with prevalence of the nonenzymatic reactions was detected in liver microsomes of rats kept on vitamin E-deficient diet. Content of main microsomal oxygenase cytochrome P-450 was unaltered, while activity of oxidative hydroxylation of the substrate of the type I (aminopyrine) was slightly decreased. After administration of the inhibitors of free radical reactions alpha-tocopherol and ionol into the animals reactions of lipid peroxidation and metabolism of xenobiotics were corrected to some degree in liver microsomes. At the same time, aminotransferase activities were normalized in liver subcellular fractions.
Gubsky I.Yu. et al. Oxygenase reactions in rat liver microsomes during antioxidant deficiency // Voprosy meditsinskoi khimii. - 1988. - V. 34. -N 4. - P. 81-85.
Gubsky I.Yu. et al., "Oxygenase reactions in rat liver microsomes during antioxidant deficiency." Voprosy meditsinskoi khimii 34.4 (1988): 81-85.
Gubsky, I. Yu., Zadorina, O. V., Paramonova, G. I., Sudarikova, L. G., Prady, T. P. (1988). Oxygenase reactions in rat liver microsomes during antioxidant deficiency. Voprosy meditsinskoi khimii, 34(4), 81-85.