VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation

   
Kuznetsov V.A., Mordvintsev P.I., Dank E.Kh., Yurkiv V.A., Vanin A.F.
PubMed Id: 2851211
Year: 1988  Volume: 34  Issue: 5  Pages: 43-46
Dinitrosyl complexes of ferrum with thiosulfate or reduced glutathione were found to inhibit completely aggregation of human thrombocytes, suspended in artificial protein-free medium. The inhibitory effect appears to occur as a result of activating action of nitrogen oxide derived from the complexes and affecting the thrombocyte guanylate cyclase.
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Kuznetsov, V. A., Mordvintsev, P. I., Dank, E. Kh., Yurkiv, V. A., Vanin, A. F. (1988). Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation. Voprosy meditsinskoi khimii, 34(5), 43-46.
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