VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

RNA-synthesizing activity of brain chromatin in rats with experimental alloxan diabetes

   
Arkhipova L.V., Kulikov A.V., Ozolin O.N.
PubMed Id: 2464237
Year: 1988  Volume: 34  Issue: 5  Pages: 76-79
Content of noradrenaline was decreased in neocortex and brain stem of rat brain by 70% and 50%, respectively, and that of serotonin--by 50% in the neocortex after development of the diabetic syndrome. At the same time, the RNA synthesizing ability of brain chromatin from the experimental animals was 3-fold higher as compared with controls. Catecholamines (L-DOPA, dopamine, noradrenaline) activated the RNA synthesis in controls by 40-50%, whereas in the animals with alloxane diabetes the effect was distinctly decreased. In vitro inhibitory effect of serotonin on the RNA synthesis was markedly decreased in preparations of brain chromatin from diabetic rats. Inhibitory effect of actinomycine D on the RNA synthesis was neutralized completely in controls after preincubation of the brain chromatin with L-DOPA, while only partial influence was detected in diabetic rats.
Download PDF:  
Citation:

Arkhipova, L. V., Kulikov, A. V., Ozolin, O. N. (1988). RNA-synthesizing activity of brain chromatin in rats with experimental alloxan diabetes. Voprosy Meditsinskoi Khimii, 34(5), 76-79.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►