VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Stimulation with triiodothyronine of the synthesis of DNA, total proteins, nuclear proteins and nuclear matrix proteins in cultured cells of hepatoma Morris 7777

   
Adylova A.T., Atakhanova B.A.
PubMed Id: 3238933
Year: 1988  Volume: 34  Issue: 6  Pages: 113-117
Intensity of DNA and protein biosynthesis was decreased in Morris hepatoma 7777 cultivated cells in absence of thyroid hormones. Physiological concentrations of triiodothyronine increased synthesis of DNA and total proteins after lag phase within 12-48 hrs, while synthesis of nuclear and nuclear matrix proteins was stimulated already within 2 hrs. This suggests that stimulation of nuclear proteins biosynthesis occurred prior to the hormone effect on proliferation and cell metabolism. Alterations in sensitivity of chromatin to DNAase I were not observed. Response of the Morris hepatoma cells to thyroid hormones may be used in studies of molecular mechanisms of thyroid hormones action.
Download PDF:  
Citation:

Adylova, A. T., Atakhanova, B. A. (1988). Stimulation with triiodothyronine of the synthesis of DNA, total proteins, nuclear proteins and nuclear matrix proteins in cultured cells of hepatoma Morris 7777. Voprosy Meditsinskoi Khimii, 34(6), 113-117.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►