VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

A radioindicator method of determining the activity of pancreatic lipase in the body

   
Kendysh I.N., Brattsev V.A., Klimova T.V., Klimova A.I.
PubMed Id: 2741392
Year: 1989  Volume: 35  Issue: 1  Pages: 137-140
125I-p-iodophenyllaurate proved to be a suitable substrate of lipase for studies of pancreas lipolytic function in vivo and in vitro. After peroral administration into rats the drug was hydrolyzed by lipase. The liberated 125I-p-iodophenol was absorbed in intestine and excreted with urine either as free 125I-p-iodophenol or its conjugates. Activity of pancreatic lipase was measured on the basis of radioactivity estimation of urine per min.
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Kendysh, I. N., Brattsev, V. A., Klimova, T. V., Klimova, A. I. (1989). A radioindicator method of determining the activity of pancreatic lipase in the body. Voprosy Meditsinskoi Khimii, 35(1), 137-140.
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