VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction

   
Frolova N.Iu., Printsev M.D., Tret'iakov A.V., Kozhemiakin L.A., Korovkin B.F.
PubMed Id: 2568032
Year: 1989  Volume: 35  Issue: 1  Pages: 64-68
Distinct increase and then decrease in content of cyclic nucleotides was observed in dog myocardium ventricles and auricles within early periods of heart infarction (10 min-4 hrs). Within a day after ligation of artery the ratio cAMP/cGMP was considerably decreased as a result of activation of guanylate cyclase and cAMP-phosphodiesterase as well as due to a decrease in activity of adenylate cyclase. Acute ischemia of small area of the heart left ventricle caused impairment of cyclic nucleotide metabolism in all the heart muscle.
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Frolova, N. Iu., Printsev, M. D., Tret'iakov, A. V., Kozhemiakin, L. A., Korovkin, B. F. (1989). The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction. Voprosy meditsinskoi khimii, 35(1), 64-68.
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